Update: Use the Mac OS X installer available at nodejs.org
And of course, you want Express to give your application a kick-start:
npm install express
And if you want to do DOM manipulation on the server-side:
npm install jquery
Enjoy. If you don’t know what these things are, here are the links: Node, NPM, Express, jQuery
In a nutshell — a whole lot of event-driven JavaScript awesome on the server side.